INFLAMMATION MAY ACCELERATING CANCER

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In normal conditions, inflammation is a biological process that the body uses to fight infection. Left unchecked, chronic inflammation is associated with diseases ranging from arthritis to cancer.

Vijaya L. Iragavarapu-Charyulu, from Florida Atlantic University (Florida, USA), and colleagues completed a study of laboratory mice that suggests that inflammation increases the level of a biomarker known cancer known as chitinase-3-like- 1 (CHI3L1), in inflamed tissue, which leads to an increase of metastasis and cancer growth faster in that tissue. The team introduced in the study a subgroup of topigeneticamente modified so that they were no longer able to produce the glycoprotein CHI3L1. The team then led the two groups of mice to become asthmatic, and then the mice were challenged with breast cancer cells. After four weeks, the researchers noted that there was less inflammation in mice lacking expression CHI3L1, and that the tumors in these mice had not grown faster. These mice also had fewer lung metastases.

Conclude the authors of the study: "Understanding how inflammation influences the CHI3L1 and how inflammation affects the tumor could result in targeted therapies preventive".

Source: Worldhealth

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Supplements against inflammation