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Scientists have discovered that the key metabolites in blood, comparable to 'fingerprint' formed as a result of molecular changes before birth or in early childhood - may provide clues to the long-term overall health of a person and the rate of aging in old age advanced. 


Ana M. Valdes, from King's College London (UK), and colleagues performed a metabolic profiling between 3000 pairs of twins enrolled in an international study. The process has revealed a collection of 22 metabolites related to aging. One particular metabolite - C-glyTrp - is associated with a range of characteristics such as age-related lung function, bone mineral density, cholesterol and blood pressure. Its role in the aging process is a recent discovery.Especially, the researchers found is associated with a lower weight at birth: this finding suggests that the levels of this metabolite, which can be determined in the womb and influenced by nutrition during development, might reflect an accelerated aging in adult life.


Scientists claim that these markers of aging could be identified by simple blood tests, in the future, thus providing additional components for your own aging process and for the development of adequate therapies.

Professor Tim Spector, director of the Department of Research at King's College London, said: 'Scientists have long known that the weight of a person at birth is an important determinant of health in middle age and in old age, and that people with low birth weight are more susceptible to age-related diseases. So far, the molecular mechanisms that link low birth weight to disease in old age had remained elusive, but this discovery has proved to be one of the molecular mechanisms involved '.


To explore the link between birth weight and the metabolite, researchers have shown through genetic testing that the gene affects levels could be modified epigenetically (for which genes are activated or deactivated by chemical switches triggered by the environment or lifestyle). These epigenetic changes may therefore affect the metabolism during the life of a person, which in turn influence their risk of age-related diseases.


Ana Valdes said: 'The human aging process is influenced by genetic, lifestyle and environmental, but the genes may explain only part of the story. Molecular changes that influence how we age in time are triggered by epigenetic changes. "

The study has been published on '"International Journal of Epidemiology."


Source: Worldhealth




Antioxidant Supplements



Supplements that promote Metabolism