Antioxidant supplements





We call senescent cells, the cells that have stopped dividing, and that accumulate with age and accelerate the aging process.

Researchers have identified new therapeutic agents that alleviate the symptoms of frailty, improve heart function and extend lifespan.


Y. Zhu, from Mayo Clinic (Minnesota, USA), and colleagues then developed senolytics: a new class of drugs that, in animal models significantly slows the aging process. First, the researchers had to identify and select the senescent cells without harming other cells. They found that senescent cells have increased expression of "networks pro-survival" that help them resist apoptosis or programmed cell death. The team then identified the dasatinib, a cancer drug; and quercetin, a natural compound with anti-inflammatory effects, as products able to selectively induce death of senescent cells. The researchers then examined how these drugs act in aging mice. In mice, cardiovascular function is improved within five days of taking a single dose of compounds combined. A single dose has led to a better exercise capacity in animals weakened by radiation therapy used for cancer. The effect lasted for at least seven months after treatment. The periodic administration to mice with accelerated aging has extended the lifespan in animals, delaying the symptoms related to age.


The study's authors argue that: "These results demonstrate the feasibility of selective ablation of senescent cells and efficacy of some active ingredients to relieve the symptoms of frailty and increase the life span."


Source: Worldhealth



Antioxidant supplements