THE GENE RESPONSIBLE FOR AGEING
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It is a kind of eternal question: can we slow down or even reverse the aging process? Although genetic manipulations can modify some cellular dynamics, little is known about the mechanisms of the aging process in living organisms.
Scientists at The Scripps campus Research Institute (TSRI) in Florida have discovered in animal models that a single gene plays a surprising role in the aging process: a discovery that could help in the coming years, to intervene in the aging process, slowing it.
The Scripps Research Institute (TSRI) is one of the largest independent research centers, not-for-profit world, specializing on research in the field of biomedical sciences. TSRI is internationally recognized for his contributions to science and health, including its role in laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia and other diseases.
"We believe that the development of a gene formerly known as Spns1 may mediate the aging process," said Shuji Kishi, who led the study, published recently in the journal PLoS Genetics. "Even a partial loss of function of Spns1 can accelerate aging."
Using various genetic approaches to disrupt Spns1 during the embryonic stages, the scientists were able to produce some models, with a lifetime of reduced or long
While most of the studies on aging have focused on the late stages of cell life, this study explored the phenomenon of aging in the early stages.
The new study shows that Spns1, in combination with a couple of other tumor suppressor genes, beclin 1 and p53 may affect the process of aging by two mechanisms differentials. In addition to affect senescence, Spns1 prevents autophagy, the process by which cells eliminate unwanted proteins or destructive and needs energy balance during the various stages of life.
On their derivanrti insights from this study, Kishi and colleagues noted that future therapies may be able to slow aging by acting on Spns1.
Source: Worldhealth
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